Strong long-term clinical evidence demonstrated in a unique long-term study of eczema in children spanning 2, 4, 6 and 11 years
Strong long-term clinical evidence demonstrated in a unique long-term study of eczema in children spanning 2, 4, 6 and 11 years
A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial.1
A protective effect of Lactobacillus rhamnosus HN001 against eczema in the first 2 years of life persists to age 4 years.2
Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: does it also reduce atopic sensitization?3
Effects of Lactobacillus rhamnosus HN001 in early life on the cumulative prevalence of allergic disease to 11 years.4
To understand if the daily intake of L. rhamnosus HN001™ and Bifidobacterium animalis ssp. lactis HN019™* would reduce the incidence and the severity of eczema in children.
Two-center, randomized, placebo-controlled
The probiotic strain in UpSpring Dual Prenatal Immunity, HN001™ was associated with a significant decrease in the cumulative prevalence of eczema for baby when taken during pregnancy1-4
HN001™ was associated with a significant decrease in the cumulative prevalence of eczema with SCORAD ≥10 over 6 years1-3
HN001™ was associated with a significantly lowered prevalence of allergic sensitization at 6 and 11 years3,4
*HN019™ did not demonstrate any effect; therefore, only HN001™ results are shown.
REFERENCES:
1. Wickens K, Black P, Stanley TV, et al. A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol. 2008;122(4):788-794 2. Wickens K, Black P, Stanley TV, et al. A protective effect of Lactobacillus rhamnosus HN001 against eczema in the first 2 years of life persists to age 4 years. Clin Exp Allergy. 2012;42(7):1071-1079. 3. Wickens K, Stanley TV, Mitchell EA, et al. Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: does it also reduce atopic sensitization? Clin Exp Allergy. 2013;43(9):1048-57. 4. Wickens K, Barthow C, Mitchell EA, et al. Effects of Lactobacillus rhamnosus HN001 in early life on the cumulative prevalence of allergic disease to 11 years. Pediatr Allergy Immunol. 2018 Dec;29(8):808-814. doi: 10.1111/pai.12982. 5. Wickens K, Barthow C, Mitchell EA, et al. Maternal supplementation alone with Lactobacillus rhamnosus HN001 during pregnancy and breastfeeding does not reduce infant eczema. Pediatr Allergy Immunol. 2018;29(3);296-302. doi: 10.1111/pai.12874.
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